It is certain than Calorie Restriction (CR) in rodents extends their lifespan, as shown by numerous studies. Exactly how calorie restriction promotes longevity is not clear, though a low level of a factor in the blood called IGF-1 might be involved, it is thought.
To test this, researchers tested whether calorie restricted human had a low level of IGF-1, as restricted rodents have; they had not.
The researchers did confirm what was already known or suspected; a low intake of protein reduces IGF-1 levels.
Thus, if low IGF-1 does turn out to be an important factor in the longevity of calorie-restricted rodents, to emulate them, humans may need to carefully evaluate their own intake of protein.
Article at WordHealthNet

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