Resveratrol From Red Wine

More evidence shows benefits of taking Resveratrol supplements – the anti-aging antioxidant derived from red wine.

A meta-study at the University of Florida showed that resveratrol appeared to have anti-aging, anti-carcinogenic, anti-inflammatory and antioxidant properties.

The study aimed to collate all knowledge to date about the effects of resveratrol, and covered thousands of laboratory studies. This important task often serves to point out the general direction of a body of research: and the general direction of this research seems to point in the direction of supplementing with resveratrol.

Up to now, there have been few human studies involving resveratrol: so its benefits are not yet certain. Nearly all the studies have been on animals. But the potential benefits of resveratrol are undeniable.

The authors make the point that the apparent ability of resveratrol to lessen human frailties will become more important as 76 million baby boomers in the USA alone head towards older age.

University of Florida news article

Related Articles About Red Wine And Resveratrol

• Recent Study – Red Wine Helps Prevent Heart Disease (lizpalmer.wordpress.com)
• Red wine, grapes and nuts can fight radiation sickness (news.bioscholar.com)
• Researchers evaluate red wine compound for treating concussions in pro boxers (sciencedaily.com)
• Resveratrol and Weight Loss (brianeraines.wordpress.com)

More Evidence For Resveratrol Health Boost is a post from: Living To 150

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As you may know, Aubrey de Grey is one of the leading lights in anti-aging research in the UK: and perhaps worldwide. He is a fascinating speaker and highly knowledgeable.

The video below will really get you thinking about the aging process, and whether it is inevitable….. Aubrey de Grey is very convincing and clearly well informed. He is a joy to listen to.  Check it out!

Related articles on Aubrey de Grey

• Aubrey de Grey on Singularity 1 on 1: Better Funding and Advocacy Can Defeat Aging (singularityblog.singularitysymposium.com)
• Aubrey de Grey on the Harvard Mouse News (acceleratingfuture.com)
• James Ellobogen clarifies nanoprocessor speed potential and projects shrinking it by 1000 times and Aubrey de Grey on the telomere research (nextbigfuture.com)

Anti-Aging Cure Found?

Aubrey de Grey – a fascinating man to listen to.

Video By Aubrey de Grey – Fascinating is a post from: Living To 150

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1. How We Can Combat Aging And Live Forever

Aubrey de Grey, brilliant researcher, interesting speaker, and a man with quite a remarkable beard – is a fascinating man to listen to.

He is the person – very prominent in anti-aging circles (sorry-that should be “gerontology”) who has reduced the matter of aging to seven body processes. And he says that all these seven can potentially be reversed.

In a sense, he has reduced ageing to an engineering issue.

This is not complete pie-in-the-sky. Certainly, some of the seven processes he has identified are already on their way to being solved. And there is absolutely no doubt that others of them will be very advanced in, say, 25 to 30 years.

Aubrey De Grey is a fascinating man to listen to and this is a great video to start with if you have not heard him before. He has the authority of a learned scientist with a highly logical frame of mind.

Aubrey de Grey at TEDMED 2009

Aubrey de Grey passionately talks about the ultimate quest for significantly longer, healthier life!

Related articles on Aubrey de Grey and Anti-Aging

• BigThink’s Series on Longevity: A Fun Place To Start (video) (singularityhub.com)
• Aubrey de Grey on the Harvard Mouse News (acceleratingfuture.com)

How We Can Combat Aging And Live Forever is a post from: Living To 150

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1. Sirtuins May Hold The Anti-Aging Key… Or May Not

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Sirtuins excite various researchers – and consumers of pills – in the anti-aging movement.

The way this works, is that sirtuins are proteins produced by the SIRT1 and SIRT3 genes. In yeast, and later in roundworms, the situins have been found to extend life. Once this was discovered, ways were looked for him to increase the production of the sirtuins. After much research resveratrol – present in red wine – was identified as having this property.

However, not everybody is convinced that this is a viable line of research for anti-aging therapy.

For example, fightaging.org points out that “messing around with metabolic fixes” such as this is a distraction from the path towards proper anti-aging techniques. The site points out that the reason so much attention is focused on sirtuins is partly due to the huge amounts of money which had been poured into it.

A more promising line of research, the site opines, would be to investigate how  the damage to the cell’s mitochondria could be reduced over time. The mitochondria – which are the “powerhouse” – the energy source – of our cells.

Various lines of research point of this as being a more fundamental break on longevity than the than the effects of the sirtuins.

Here is the very interesting post:

Promising Line of Research for Anti-Aging

Related articles about Sirtuins and Anti-aging

• Scientists ferret out a key pathway for aging (biosingularity.wordpress.com)
• Scientists ID key protein that links dietary restriction with healthy hearing, aging (physorg.com)
• Anti-ageing pill step closer as scientists finds enzyme that stops our cells from dying (dailymail.co.uk)

Sirtuins May Hold The Anti-Aging Key… Or May Not is a post from: Living To 150

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1. Sirtuins Are Worthy Candidates For Research
2. Resveratrol Enhances Breast Cancer Treatment

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Resveratrol, the polyphenol derived from red wine which appears to have anti-aging properties, has been found to have a use in anti-cancer therapy. When used alongside cancer drug rapamycin there is a strong suggestion that resveratrol enhances its treatment effect on breast cancer cells.

Rapamycin, a drug primarily used as an immunosuppressant following organ transplant, has been known to have anti-cancer properties for some time; the problem is, that after a while its effectiveness rapidly reduces as the cancer cells become resistant to it.

But when combined with the low dose of resveratrol the beneficial effects of the rapamycin are enhanced – the resistance reduces.

Specifically, a low dose of both the drug and the polyphenols served to reduce the growth of three different types of breast cancer by 50 percent in this study. This is a significant result which highlights a potentially powerful effect of the remarkable compound, resveratrol.

**The main benefit of resveratrol is that it stimulates the SIRT1 gene, and this effect has been shown to extend life in yeast cells, and in roundworms sells. This means that it is highly likely to have this same effect on human cells.

Related articles

• Red Wine Compound Increase Anti Cancer Effect of Rapamycin (E! Science News)
• Compounds in Red Wine Fight Breast Cancer (blogwinecellar.com)
• Red wine compound increases anti-tumor effect of rapamycin (eurekalert.org)

Resveratrol Enhances Breast Cancer Treatment is a post from: Living To 150

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The telomere is a small structure attached to the end of our DNA, which shrinks slightly every time a cell divides. Once the telomere reaches a certain small size, the cell is ‘instructed’ to self-destruct.

Hence there is a great deal of interest in keeping the telomeres as long as possible. One substance which appears to help this is TA 65.

But we can help the telomere shortening to slow down – and one way is by avoiding stress.

As the video shows…

How Stress Affects Our Telomeres (Chromosome / DNA)

Stress by way of stress hormones accelerate the shortening of telomeres.

Related articles on Stress and Aging

• The Effect of Negative Thinking on Health, Wellbeing and Life Span, by Nobel Prize Winner. [Sam Borrett] (ecademy.com)
• Daily Dose: How to slow the aging process (boston.com)
• The Costs Of Stress (andrewsullivan.theatlantic.com)

Telomeres Are Subject To Stress is a post from: Living To 150

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1. Resveratrol Supplements – A Summary Of The Good News

Resveratrol Supplements have been clearly shown to have various benefits for human health. Resveratrol is the substance which was discovered to be present in red wine.

These benefits are particularly related to the reduction of cancer and also of heart disease. As these two are the two main diseases afflicting Western society, this highlights the extreme importance of resveratrol supplements.

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The Annals of the New York Academy of Sciences have recently publish a series of papers about these benefits, and the other benefits which with resveratrol has been found to have. These are summarised – in understandable form    by RevGenetics.

Resveratrol has such clear benefits for health that I can only wonder how long it going to take before it becomes more widely used by the population at large.

Related articles about Resveratrol and Resveratrol Supplements

• Resveratrol and quercetin tame inflammation and prevent insulin resistance (gracemedeirosmj.wordpress.com)
• Resveratrol May Suppress Inflammation in Humans (webmd.com)
• Resveratrol’s Benefits Linked To Fat Hormones (gracemedeirosmj.wordpress.com)
• Nature’s Cure for Heart Disease? (everydayhealth.com)

Resveratrol Supplements – A Summary Of The Good News is a post from: Living To 150

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1. Sirtuins Are Worthy Candidates For Research

In laboratory tests, sirtuins were found to be involved in longevity. This was discovered because cells would live much longer when one of their genes – SIRT1 – was stimulated. This gene produces the sirtuin proteins.

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Furthermore, when the activity of the SIRT1 gene was reduced, the yeast cells died sooner.

The same effect was later found in experiments on roundworms. this coincident effect led scientists to believe that exactly the same would happen with humans – who share a very large proportion of their DNA with both yeast and roundworms.

This led to a search for nutrients which would naturally stimulate the SIRT1 (and SIRT3) gene, and the discovery of resveratrol in red wine.

Resveratrol is now seen as a very promising candidate for research in anti-ageing medicine.

The role of Sirtuins in aging is covered nicely in this article which includes the section: “SIRT3: Balancing Cancer and Aging”

Related articles on Sirtuins and SIRT1 and SIRT3

• Movie star SIRT1 makes for a great body but an old brain (genes2brains2mind2me.com)
• SIRT1 gene important for memory (eurekalert.org)

Sirtuins Are Worthy Candidates For Research is a post from: Living To 150

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There is no doubt that anti-aging research is slowed down hugely by unnecessary bureaucracy.

Researchers in the field spend far too much of their time dealing with regulatory matters and too little of their time actually doing the anti-aging research they love. Much more of their time is spent in raising money to fund an area of research in which government has little interest.

In future years, the current regulatory environment will be seen as sheer madness. This research will, in 20-40 years, produce massive relief from suffering and avoidance of many of the diseases of old age. The burden on society that such ailments cause will also be massively reduced.

As usual, government is being short-sighted. No surprise there. What would we give for an enlightened leader?

Of course some regulation is necessary: but not the amount which so massively reduces the rate at which problems are solved such as recovery from stroke, the conquering of cancer, and of Alzheimer’s and Parkinson’s.

Here is a post by someone who deals with this type of excessive regulation every day.

Regulation Slows Down Anti-Aging Research is a post from: Living To 150

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Gigi at Anti Aging Nutrition News has an interesting comments thread on TA-65 supplement.

This is the ‘supplement of the moment’, which repairs the ‘telomere’ each time the cell divides – which process otherwise eventually contributes to the cell’s decision to self-destruct. That is, it leads to death. 

Although the cost of TA-65 has come down a lot, it is still expensive. Add to that the possible need for a few grand’s worth of testing, is gets pricier still.

Read through the comments at Gigi’s blog, though, and you will find recommendations for getting much of the benefit of TA-65 without all the expense.

This is a fascinating topic – and a fascinating supplement. Along with resveratrol it is the substance with the most promise in the anti-aging field.

Related articles about the TA 65 Supplement

• Is There A Secret To Eternal Youth? (newyork.cbslocal.com)
• BodyLogicMD Physicians Recommend Pharmaceutical Grade Supplements (prweb.com)

TA-65 Supplement: More Info & A Possible Low-Cost Substitute is a post from: Living To 150

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Aubrey de Grey is one of the top UK commentators on anti-aging. He is a Cambridge ‘Don’ who is very knowledgeable about this fascinating topic.

Aubrey has reduced aging to an engineering issue: he has narrowed it down to 7 problems which need to be solved – and most of them are on the way.

So it’s just a matter of time…

Aubrey de Grey: Why we age and how we can avoid it

www.ted.com Cambridge researcher Aubrey de Grey argues that aging is merely a disease — and a curable one at that. Humans age in seven basic ways, he says, all of which can be averted. TEDTalks is a daily video podcast of really great talks and performances.

Aubrey de Grey – Ending Aging

Dr Aubrey de Grey believes that we do not have to age and die after three score years and ten. Watch a remarkable visionary introduce his ideas.

Related articles to Aubrey de Grey and Anti-aging

• Aubrey dr Grey in GQ magazine and BBC news and Genescient’s Stem Cell 100 (nextbigfuture.com)
• Aubrey de Grey on the Harvard Mouse News (acceleratingfuture.com)
• Aubrey de Grey and David Brin Discuss When Will Life Expectancy Reach 200 Years? (nextbigfuture.com)
• Living Better, Longer – And Maybe Forever (bigthink.com)

Anti-Aging – Aubrey de Grey is a post from: Living To 150

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TA-65 seems to have huge potential. Of course – there are the nay-sayers: those who will say: “It’s a rip-off”.

But that will always be so.

The thing is, TA-65 takes tons of Astragalus to make it – so it will be expensive: though as time passes cheaper ways will be found to produce it, no doubt.

This supplement works by ‘repairing’ the telomere, which otherwise degrades in human cells each time the cell divides.

Now, this is ONE way – of the 7 known ways – that aging occurs.

So you still have to deal with the other 6. HOWEVER, this appears to be a really good fix for the one-out-of-seven causes of aging. As such, we should be pleased it has been identified – and a fix found.

Of course it will get cheaper – in fact, it already has reduced in price.

Telomeres and Aging Telomerase and Aging. Call 212-588-8805 Telomere and Aging TA-65

CBS News reports on “The Fountain of Youth in a Tiny Capsule?”

CBS News reports on a nutritional supplement that improved vision in a 67 year-old.

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• Is There A Secret To Eternal Youth? (newyork.cbslocal.com)
• Telomere length as an indicator of life expectancy for the southern giant petrel (sciencedaily.com)
• Scientists Find Way to Partially Reverse Aging in Mice (nlm.nih.gov)
• TA Associates plans to bulk up with Dymatize (finance.fortune.cnn.com)

TA-65 – Supplement Of Choice is a post from: Living To 150

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Anti-Aging expert – and genius inventor – Ray Kurzweil has been made the subject of a documentary film: Transcendental Man. This explores Kurzweil’s view that by the 2030s, it will be difficult or impossible to differentiate between artificial and human intelligence. As man evolves his intelligence will be augmented by that of electronics.

Well before that time, the length of our lives will inevitably increase, and the physiological processes of aging (Aubrey de Grey has specified that there are only seven of these – and has challenged other scientists to come up with an eighth) are conquered – one by one.

This film is a ‘must watch’, and is being premiered around the world during March and April 2011. I have applied for tickets in London, April 4-5 at the Science Museum.

See the full program of premiers – which include Q and A with Ray, at this address.

Stories:

Down the avenue: Ray Kurzweil’s The Transcendent Man

This documentary film is about the life and ideas of Ray Kurzweil who continues to travel the world offering his vision of a future in which we will merge with our machines, can live forever, and are billions of times more …

FORA.tv – Ray Kurzweil: Interview and Audience Q&A

Ray Kurzweil has been described as “the restless genius” by the Wall Street Journal, and “the ultimate thinking machine” by Forbes. Inc. magazine ranked him #8 among entrepreneurs in the United States, calling him the “rightful heir to Edison…

Related Anti-Aging and Ray Kurzweil Articles

• Ray Kurzweil’s The Transcendent Man (downtheavenue.com)
• Transcendent Man Film To Be Released in February, Digitally in March (trailer) (singularityhub.com)
• Ray Kurzweil’s Slippery Futurism (tech.slashdot.org)
• Time Presents “10 Questions for Ray Kurzweil” – Hello, Mainstream (video) (singularityhub.com)
• Ray Kurzweil reviews all of his predictions for dates up to 2010 (nextbigfuture.com)

Anti-Aging Expert Ray Kurzweil’s Documentary is a post from: Living To 150

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Fish oil supplements are a great source of omega 3 fatty acids. Eating foods rich in omega 3 is another way that we can supply our body with all the fatty acids that we need. Some people would argue that we don’t need supplements. A healthy diet should be more than enough to provide us with all the essential nutrients that we need.

In the past, that statement would be more true. People didn’t need fish oil pills or supplements back then. Most of our foods don’t go through as much processing and are our grandparents’ and great grandparents’ diets are healthier. They prepared and cooked most of their foods and they used to get most of their ingredients fresh from the farm. But today, we thrive on the convenience of fast food. We hardly know where our foods comes from or how it’s prepared. And when we do cook our food, we use processed ingredients to make cooking easier and faster.

And this doesn’t include the fact that most of foods themselves today are not as healthy as they were in the last century. For example:

• Fatty fish. This used to be a good source of omega 3 fish oil . But now we have to be a bit more cautious as some fish are contaminated with heavy metals, pesticides and inorganic compounds.
• Beef. Beef used to be a good source of omega 3 back in the days when cows were allowed to graze and they were grass fed. Now cows are kept in pens and they are corn fed, so their meat contains fat with too much omega 6 and not enough omega 3 fatty acids.
• Eggs. In the past, eggs were naturally rich in omega 3 and other essential fatty acids. That’s because chickens used to be able to graze and eat insects and grass. This made the eggs more nutritious. But now chickens are kept in small coops and grain-fed. So when you eat eggs – ‘free range’ is important.
• Flaxseed. Flaxseed isn’t a very good source of omega 3 fatty acids as most people believe. Our body needs DHA and EPA omega 3 fatty acids. Flaxseed contains ALA, which the body has to convert to DHA and EPA. The problem with ALA though is only 2% of t is converted to DHA and ALA.

As you can see, we really need to take fish oil supplements everyday if we want to get all the health benefits of omega 3. Omega 3 is vital for anti-aging it has so many benefits. But get it in the right way.

Can Fish Oil Supplements Give You More Omega 3 Than Omega 3 Foods? is a post from: Living To 150

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TA-65 is a ‘supplement’ extracted from the herb Astragalus which repairs the telomere – the straggly bits at the end of our DNA wich get shorted each time our cells divide. This process – the reducing of telomere length – eventually kills us off at the age of a maximum of 120. In other words, if we were healthy enough that nothing else killed us off, the shrinking of the telomere would do so at this age.

Well, companies are now finding out how to repair the telomere. And it is resulting in increasing health and wellbeing for hundreds of people. The leader in the field is TA Sciences, who licensed the research from Geron, a leading Californian anti-aging company, who discovered it. A study showed wide-ranging anti-aging benefits – in vision, skin condition, stamina and energy and sexual function. TA Sciences make TA-65 available to all employees over 40 years old.

The downside? There are no long-term studies on it yet, so its long-term effects are not known.

It is certainly an interesting one though – let’s face it, if you are 10-20 years from likely death anyway – what can you lose trying such a therapy – which at present looks pretty safe?

This blog is worth checking out for anti-aging information on TA-65. And Al Sears – anti-aging doctor and specialist – has a DVD on the topic which you can buy.

TA-65, Astragalus, telomere

What’s a Telomere and Why is it Important to the Aging Process

The following video is excerpted from Dr. Bill Andrew’s presentation at the Manhattan Beach Project Longevity Conference. Dr. Andrews leads the scientific research and development function of Sierra Sciences.

Related articles about TA-65, and the Telomere

• Arlene Weintraub: Scientists Can Reverse Aging in Mice, But Can They Do it for Humans? (huffingtonpost.com)
• Is There A Secret To Eternal Youth? (newyork.cbslocal.com)
• Telomere length as an indicator of life expectancy for the southern giant petrel (sciencedaily.com)
• Suck This ‘Magic Hormone’ into Your Body and Transform Your Health – Takes Just 20 Minutes (findmeacure.com)

TA-65 – Supplement Of The Moment is a post from: Living To 150

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(Here is a brief summary for new readers:  I started my anti-aging, or longevity, quest in March 2008 when I visited Fort Lauderdale for 63 blood tests. Then I had to interpret them as best as I could.)

In July 2009 I decided to get more professional input, and visited Dr Terry Grossman in Denver for a repeat of the tests, a few more besides, and more personal advice.

In October 2009 (OK – I dragged my feet a bit) I had a review, via Skype, of the results of the tests Terry had carried out for me.

Wow – Skype video! Fantastic. It was near to the effect of being in Terry Grossman’s offices.

Key Health Points

Key points were:

• My total cholesterol is high
• My genetic profile shows no particular inherited concerns
• My biological age is 19 years younger than my physical age – a near record for the clinic
• I need to enhance my exercise regime to keep up the good results I have had.

I am now starting my ‘new regime’. My main aim is to reduce my cholesterol – through diet  and supplements.

My Health – The Next Step is a post from: Living To 150

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This is a great ebook which does a good job of explaining where we are today with regard to healthy anti-aging strategies.

Best of all – it is completely free. David Kekich is doing all he can to publicize anti-aging, so is giving this book away. It’s a chunky tome – and packed full of information.

It tells you 7 steps to take to: “catch the emerging wave of medical breakthroughs…” for a healthy, extended life. I strongly recommend this book to help get you up to speed with the current state of anti-aging knowledge.

Also, follow author David Kekich on twitter @MaxLifeorg .

Free Longevity Book is a post from: Living To 150

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Gosh – I’d like to go to this – the Manhattan Beach Project, Los Angeles. It’s the conference I wanted to go to when I went to Convergence08 last November: because this on is focused specifically on longevity.

The field of longevity research is getting very exciting now. Aubrey de Grey is quoted as thinking there is a 50/50 chance of his living forever.  Now, if a conservative scientist says that, you have to take note.

Unfortunately, I cannot go – I have things booked for November and can’t get away. But it’s in the diary for next year.

Apparently there will be recordings of the speakers which can be watched for free.

“You’ll get to see all of the twenty minute presentations by world-leading researchers. Each one of the fifteen presenters will also answer up to ten minutes of questions.”

Sorry to miss it. The usual suspects – Aubrey de Grey and Ray Kurzweil – will be there (albeit Kurweil will be beamed in). The whole thing is hosted by David A Kekich and Greta Blackburn of Maximum Life Foundation, and sponsored by Life Extension Foundation. Should be very good.

Follow Maximum Life Foundation on Twitter @maxlifeorg .

Longevity Conference, November 2009 is a post from: Living To 150

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Do you take good care of your teeth?

I go to a local dentist who answers my questions and I think does a reasonable job. But how good is it? I will check – by visiting Harley Street.

Visiting a dentist is a bit like having your car mended – how do you judge it has been done well?

Well, I thought it might be interesting for my readers, to have a thorough review of my own tooth health so I could see if everything was as fine as I thought.

This is an anti-aging issue – because present or future infections in the tooth or worse, in the root canal, can spew out toxins into the body, seriously affecting it.

The Plan

I have been researching a very good dentist, and have found one who I think is extremely good as well as being a warm person. I will first go for a consultation to see what she says about my teeth in general. If I am happy, I will then proceed as a guinea pig, carrying out her recommendations, and keeping you informed about the progress and the results.

As I go along, I will tell you what I learn, so you can apply that to your own situation.

It is likely to cost quite a bit of money – but I think it is worth it. And I will find out whether my confidence in my current dental arrangements is well placed.

Teeth Review is a post from: Living To 150

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I have now received a comprehensive written report from visiting Dr Terry Grossman’s clinic in Denver. There are few surprises.

Blood sugar is a little higher than I would like. Homcysteine is higher than it was last year; that means increased heart disease risk so I will increase B vitamins and folic acid to deal with this.

My LDL cholesterl is even higher than last year. However, this time a VAP test (more in depth that the usual cholesterol test) reveals that many of these LDL particles are the worse, smaller kinds, which are more of a heart risk.

I will need to address this. How, I will know after talking to Terry Grossman for my follow-up consultation.

Apart from this news is good. Inherited factors are not bad; my ‘H-scan’ result places me at 38 years old biologically -  19 years younger than my physical age; and one or two environmental toxns need sorting out with a course of chelaton therapy.

After my telephone consultaton I will carry out Terry’s recommendations.Then he wants some repeat blood tests to monitor the hoped-for improvements.

So I will probably pop over to New York to have the retests. This seems crazy but is necessary for three reasons: 1. It’s good if the same lab does the tests – for comparison purposes; 2. Blood tests cost a fortune in the UK: 3. Sending blood to the States is very expensive – and if it’s delayed, it’s ‘dead’.

Anyway, it’s an excuse for a few days’ break in New York. I can go and see the stunning gospel choir in the Bronx I saw last time.

I also plan to try and get my parents to go over to have some basic blood tests at that time.

Question: Would you travel 3000 miles to get blood tests if you knew it would help you look after your health – and possible avoid cancer and heart disease? Leave a comment.

Health Report Has Arrived is a post from: Living To 150

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