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	<title>Living To 150 &#187; Fibrinogen</title>
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	<description>Expect to be surprised - and live to be a healthy 150. Here&#039;s how.</description>
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		<title>Inflammation Kills</title>
		<link>http://livingto150.com/inflammation-kills/</link>
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		<pubDate>Thu, 04 Sep 2008 08:44:42 +0000</pubDate>
		<dc:creator>Malc</dc:creator>
				<category><![CDATA[Health Essentials]]></category>
		<category><![CDATA[Aging]]></category>
		<category><![CDATA[blood]]></category>
		<category><![CDATA[Blood tests]]></category>
		<category><![CDATA[C-reactive protein]]></category>
		<category><![CDATA[Cancer]]></category>
		<category><![CDATA[CRP]]></category>
		<category><![CDATA[Diabetes]]></category>
		<category><![CDATA[Diet]]></category>
		<category><![CDATA[Fibrinogen]]></category>
		<category><![CDATA[health]]></category>
		<category><![CDATA[heart]]></category>
		<category><![CDATA[Heart disease]]></category>
		<category><![CDATA[inflammation]]></category>
		<category><![CDATA[longevity]]></category>

		<guid isPermaLink="false">http://livingto150.com/2008/09/04/inflammation-kills/</guid>
		<description><![CDATA[Inflammation is shown, in this image, affecting some of the major joints. We all know and understand this type. But Generalised Inflammation is something that we all need to be aware of &#8211; whether or not we have aches and pains. Generalised Inflammation is present in many people &#8211; and they rarely know about it. [...]<p><a href="http://livingto150.com/inflammation-kills/">Inflammation Kills</a> is a post from: <a href="http://livingto150.com">Living To 150</a></p>

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			<content:encoded><![CDATA[<p></p><div class="zemanta-img" style="display: block; float: right; margin: 1em"><span class="zemanta-img-attribution"></span></div>
<p><a href="http://livingto150.com/wp-content/uploads/2008/09/inflammation-150x200.jpg" ><img style="border-top-width: 0px; border-left-width: 0px; border-bottom-width: 0px; margin: 0px 5px 0px 0px; border-right-width: 0px" height="176" alt="inflammation-150x200" src="http://livingto150.com/wp-content/uploads/2008/09/inflammation-150x200-thumb.jpg" width="133" align="left" border="0" /></a> Inflammation is shown, in this image, affecting some of the major joints. We all know and understand this type.</p>
<p>But <a href="http://livingto150.com/aging-and-longevity-4-inflammation/" title="Generalised inflammation"  target="_blank">Generalised Inflammation</a> is something that we <strong>all </strong>need to be aware of &#8211; whether or not we have aches and pains.</p>
<p><a href="http://livingto150.com/aging-and-longevity-4-inflammation/" title="Generalised inflammation"  target="_blank">Generalised Inflammation</a> is present in many people &#8211; and they rarely know about it.</p>
<p>This insidious type of inflammation is implicated in all major degenerative diseases:</p>
<ul>
<li>Heart disease </li>
<li>Artery disease </li>
<li>Some cancers </li>
<li>Alzheimer&#8217;s Disease </li>
<li>Diabetes </li>
</ul>
<p>In other words, many studies have shown that a significant number of the people suffering from these diseases</p>
<p><span id="more-81"></span><br />
have generalised inflammation, demonstrated by blood tests.
</p>
<p>As these diseases occur more as we age, I think we can usefully add:</p>
<ul>
<li>Aging </li>
</ul>
<p>to the list of diseases which inflammation causes.</p>
<h3>Measuring Inflammation</h3>
<p><img style="border-right: medium none; border-top: medium none; display: block; margin: 0px 5px 0px 0px; border-left: medium none; border-bottom: medium none" height="99" alt="Picture of CRP (source Wikipedia)" src="http://upload.wikimedia.org/wikipedia/commons/thumb/a/ab/CRP_pretty.png/202px-CRP_pretty.png" width="133" align="left" />Inflammation can be detected by testing the blood for c-reactive protein <em>(molecule pictured left)</em> and fibrinogen. If the levels of these two are high, bringing them down can usually be fairly easily achieved through the right vitamins, nutritional supplements and herbs.</p>
<h3>More Information</h3>
<p>As well as my more detailed article on <a href="http://livingto150.com/aging-and-longevity-4-inflammation/" title="Generalised inflammation"  target="_blank">Inflammation</a>, here are links to some books on the topic from Amazon UK:</p>
<p><a rel="nofollow" href="http://www.amazon.co.uk/Stop-Inflammation-Now-Richard-Fleming/dp/1583332006/ref=sr_1_4?ie=UTF8&amp;s=books&amp;qid=1220517147&amp;sr=1-4" title="Stop Inflammation Now!"  target="_blank">Stop Inflammation Now!</a>    <br /><a rel="nofollow" href="http://www.amazon.co.uk/Inflammation-Syndrome-Nutritional-Arthritis-Allergies/dp/0471478814/ref=sr_1_2?ie=UTF8&amp;s=books&amp;qid=1220517147&amp;sr=1-2" title="The Inflammation Syndrome"  target="_blank">The Inflammation Syndrome</a>    <br /><a rel="nofollow" href="http://www.amazon.co.uk/Inflammation-Free-Diet-Plan-Sonberg-Books/dp/0071486011/ref=sr_1_1?ie=UTF8&amp;s=books&amp;qid=1220517147&amp;sr=1-1" title="The Inflammation-Free Diet Plan"  target="_blank">The Inflammation-Free Diet Plan</a></p>
<h3>Essential To Address If We Are To Get &#8211; And Stay &#8211; Healthy</h3>
<p>Inflammation is a crucial issue to address to slow down aging and the onset of degenerative diseases. I find it fascinating that this issue is:</p>
<ul>
<li>Easy to measure (through blood tests) </li>
<li>Usually easy to treat </li>
<li>Therefore within our individual control </li>
</ul>
<p>And also that it is:</p>
<ul>
<li>Talked about by hardly anyone who is charged with looking after our health. </li>
</ul>
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<div id="st200812134735" class="st-taf"><img alt="SocialTwist Tell-a-Friend" style="border:0;margin:0;padding:0;" src="http://images.socialtwist.com/200812134735/button.png" onmouseout="hideHoverMap(this)" onmouseover="showHoverMap(this, '200812134735',  'http%3A%2F%2Flivingto150.com%2Finflammation-kills%2F', 'Inflammation+Kills')" onclick="cw(this, {id:'200812134735',link: 'http%3A%2F%2Flivingto150.com%2Finflammation-kills%2F', title: '+Inflammation+Kills+' })"/></div><p><a href="http://livingto150.com/inflammation-kills/">Inflammation Kills</a> is a post from: <a href="http://livingto150.com">Living To 150</a></p>
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		<title>Aging and Longevity &#8211; 4. Inflammation</title>
		<link>http://livingto150.com/aging-and-longevity-4-inflammation/</link>
		<comments>http://livingto150.com/aging-and-longevity-4-inflammation/#comments</comments>
		<pubDate>Thu, 21 Aug 2008 06:00:30 +0000</pubDate>
		<dc:creator>Malc</dc:creator>
				<category><![CDATA[Health News]]></category>
		<category><![CDATA[Aging]]></category>
		<category><![CDATA[anti-aging]]></category>
		<category><![CDATA[C-reactive protein]]></category>
		<category><![CDATA[Cancer]]></category>
		<category><![CDATA[CRP]]></category>
		<category><![CDATA[Diet]]></category>
		<category><![CDATA[Fibrinogen]]></category>
		<category><![CDATA[Glycation]]></category>
		<category><![CDATA[health]]></category>
		<category><![CDATA[Heart disease]]></category>
		<category><![CDATA[inflammation]]></category>
		<category><![CDATA[life extension]]></category>
		<category><![CDATA[longevity]]></category>
		<category><![CDATA[oxidation]]></category>

		<guid isPermaLink="false">http://livingto150.com/?page_id=60</guid>
		<description><![CDATA[Low-level inflammation causes millions to die every year. This type of inflammation can easily be identified with a simple blood test. Usually, it can easily be treated with a combination of all herbs and nutrients. In years to come it will be measured routinely, because it is such an effective predictor of disease. What Is [...]<p><a href="http://livingto150.com/aging-and-longevity-4-inflammation/">Aging and Longevity &#8211; 4. Inflammation</a> is a post from: <a href="http://livingto150.com">Living To 150</a></p>

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			<content:encoded><![CDATA[<p></p><p>Low-level inflammation causes millions to die every year. This type of inflammation can easily be identified with a simple blood test. Usually, it can easily be treated with a combination of all herbs and nutrients. In years to come it will be measured routinely, because it is such an effective predictor of disease.</p>
<h3>What Is Low Level Inflammation?</h3>
<p>We generally know when we have an inflammation, because it is characterized by the classic indications of heat, swelling, redness and pain.</p>
<p>However when there is low-level inflammation there are no obvious external signs. But what is certain is that this <strong>low level inflammation</strong> is an accurate predictor of many serious diseases.</p>
<h3>What Problems Does It Create?</h3>
<p>There is very clear data showing that low-level inflammation makes heart and artery disease much more likely. This has been confirmed by analyzing the results of major studies.</p>
<p>By itself, this is a very important factor in health and aging. Ofter all, half the population of Western countries die of heart and artery disease.</p>
<p>But there is more. Low-level inflammation is also an accurate predictor of many other degenerative diseases, including;</p>
<ol>
<li>Alzheimer&#8217;s disease</li>
<li>Arthritis and rheumatism, and</li>
<li>Some, probably many, cancers</li>
</ol>
<h3>How Can It Be Measured?</h3>
<p>The actual causative factors of inflammation &#8211; inflammatory cytokines &#8211; can be measured; but this is expensive. It is better first to measure two blood components which indicate the presence or absence of inflammation; then home in on the cytokines only if necessary.</p>
<p>These two blood components, which accompany inflammation, are easily and (fairly) cheaply measured. They are c-reactive protein (CRP) and fibrinogen. In the UK you might even get your doctor to get these measured for you.</p>
<p>If these two are very high and there is no obvious inflammation present (such as an infection), then some sort of low level inflammation is present. This inflammation will be wearing out body tissues and certainly leading us towards degenerative diseases.</p>
<p>The level of CRP you are aiming for is less than 1 mg/L (milligram per litre) for men, and less than 1.5 mg/L for women (Philip Miller, 2005, p184 &#8211; see end of next paragraph). Over 2 mg/L for men and 3.5 mg/L for women leads to significant additional risk for heart disease, and other degenerative diseases.</p>
<h3>How Can Inflammation Be Treated?</h3>
<p>Low-level inflammation can be treated through diet and by using supplements.</p>
<p><em>Diet:</em> this is pretty much the standard anti-aging diet, namely:</p>
<ol>
<li>Plenty of fresh vegetables, many of them preferably raw.</li>
<li>Reduce to a minimum potatoes, pasta, bread and rice.</li>
<li>Reduce all types of sugar to a minimum &#8211; honey and maple syrup included</li>
<li>Moderate amounts of fruit, mainly berries, eaten whole and not as juice.</li>
<li>Choose foods low on the glycemic index.</li>
<li>Eat healthy fats. Apart from trans fats and saturated fats, which should obviously be avoided, Omega 6 fatty acids promote inflammation. These are present in most oils except olive oil, and in meat and dairy products as well as in grains. Grass-fed meat is lower in Omega 6 fats than grain-fed meat. Omega 3 fatty acids on the other hand, are anti-inflammatory. They are found in olive oil, nuts, seeds and fish and in vegetables in small amounts.</li>
</ol>
<p><em>Supplements:</em> The top supplement to take to reduce generalised inflammation is <strong>fish oil</strong>. All adults are advised to take at least 1 gramme of DHA + EPA daily, and up to 3 grammes.  Probably 2 grammes is good to aim for. This is provided by 6 capsules a day of the typical omega 3 supplement &#8211; but check the label &#8211; some are stronger than others. Look on the label for the level of EPA and DHA and add them together.  You are looking for 2 grammes or 2000 mg. (Ignore the total amount of fish oil &#8211; you are looking just for EPA and DHA.)</p>
<p>Other anti-inflammatory supplements include bromelain &#8211; from pineapple, the hormone DHEA and vitamin K.</p>
<p>Herbs which can counteract low-level inflammation include natural, ginger, turmeric and ginkgo.</p>
<p>The exact treatment protocol use will be best determined by a professional you&#8217;re working with. Or you might start with that given in <em>Philip Miller</em>&#8216;s excellent book &#8220;<em>Life Extension Revolution</em>&#8221; (2005 edition, page 194).</p>
<h3>The 4 &#8216;-ations&#8217; &#8211; Essential Indicators of Health</h3>
<p>The 4 &#8216;-ations&#8217; &#8211; which include inflammation &#8211; are four very damaging processes which cause aging and which produce the degenerative disease which kill most of us. The other three of these processes are <a href="http://livingto150.com/aging-and-longevity-methylation/" title="Aging and Longevity - Methylation" >methylation</a>, <a href="http://livingto150.com/aging-and-longevity-oxidation/" title="Aging and Longevity - Oxidation" >oxidation</a> and <a href="http://livingto150.com/aging-and-longevity-glycation/" title="Aging and Longevity - Glycation" >glycation</a>.</p>
<p>The knowledge of how to deal with these 4 killers is growing rapidly, mainly among the few researchers who are interested in longevity or healthy aging.</p>
<p>It typically takes 25 years for the medical profession to absorb new information of this magnitude. This means it is up to us as individuals to learn about, and take control of, these processes.</p>
<p>Fortunately, the evidence is clear and the solutions are quite simple. To me, this is an absolutely fascinating topic. I hope I have conveyed that to you in these four articles, and that you find them useful.</p>
<div id="st200812134735" class="st-taf"><img alt="SocialTwist Tell-a-Friend" style="border:0;margin:0;padding:0;" src="http://images.socialtwist.com/200812134735/button.png" onmouseout="hideHoverMap(this)" onmouseover="showHoverMap(this, '200812134735',  'http%3A%2F%2Flivingto150.com%2Faging-and-longevity-4-inflammation%2F', 'Aging+and+Longevity+%26%238211%3B+4.+Inflammation')" onclick="cw(this, {id:'200812134735',link: 'http%3A%2F%2Flivingto150.com%2Faging-and-longevity-4-inflammation%2F', title: '+Aging+and+Longevity+%26%238211%3B+4.+Inflammation+' })"/></div><p><a href="http://livingto150.com/aging-and-longevity-4-inflammation/">Aging and Longevity &#8211; 4. Inflammation</a> is a post from: <a href="http://livingto150.com">Living To 150</a></p>
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		<title>Arthritis and Inflammation</title>
		<link>http://livingto150.com/arthritis-and-inflammation/</link>
		<comments>http://livingto150.com/arthritis-and-inflammation/#comments</comments>
		<pubDate>Thu, 03 Jul 2008 22:47:28 +0000</pubDate>
		<dc:creator>Malc</dc:creator>
				<category><![CDATA[Health Essentials]]></category>
		<category><![CDATA[Aging]]></category>
		<category><![CDATA[arthritis]]></category>
		<category><![CDATA[blood]]></category>
		<category><![CDATA[Blood tests]]></category>
		<category><![CDATA[C-reactive protein]]></category>
		<category><![CDATA[Cancer]]></category>
		<category><![CDATA[CRP]]></category>
		<category><![CDATA[Diet]]></category>
		<category><![CDATA[Fibrinogen]]></category>
		<category><![CDATA[health]]></category>
		<category><![CDATA[heart]]></category>
		<category><![CDATA[inflammation]]></category>
		<category><![CDATA[life extension]]></category>
		<category><![CDATA[longevity]]></category>
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		<guid isPermaLink="false">http://livingto150.com/2008/07/03/arthritis-and-inflammation/</guid>
		<description><![CDATA[A friend was concerned about arthritis as she aged. Having an aging father in law in poor health made her think of her own state of health. Systemic inflammation is one factor to take seriously. Systemic inflammation is when there is general &#8216;background&#8217; inflammation without pain or symptoms &#8211; at least initially. For this reason [...]<p><a href="http://livingto150.com/arthritis-and-inflammation/">Arthritis and Inflammation</a> is a post from: <a href="http://livingto150.com">Living To 150</a></p>

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			<content:encoded><![CDATA[<p></p><p>A friend was concerned about arthritis as she aged. Having an aging father in law in poor health made her think of her own state of health. <strong>Systemic inflammation</strong> is one factor to take seriously.</p>
<p><strong>Systemic inflammation </strong>is when there is general &#8216;background&#8217; inflammation without pain or symptoms &#8211; at least initially. For this reason it is insidious as it can just creep up on you. The joints and muscles can slowly degenerate without you realising it.</p>
<p>The same inflammation is a major cause of a host of other diseases including heart and artery disease; some cancers; Alzheimer&#8217;s disease, as well as conditions due to thickened blood such as angina and clouded thinking.</p>
<p><strong>Systemic inflammation</strong> can be indicated through blood tests for <strong>C-reactive protein (CRP)</strong> and <strong>fibrinogen</strong>. If both of these are low, this is a good sign that  systemic inflammation is not rampant in your body.</p>
<p>My own measures for these two are: <strong>CRP</strong> &#8211; 0.82 mg/L, and 149 mg/dL of <strong>fibrinogen</strong>. The &#8216;reference range&#8217; (range within which the lab suggests the results are ok) for <strong>CRP </strong>is 0-3 mg/L and for <strong>fibrinogen</strong> 193-423 mg/dL.</p>
<p>This makes my <strong>CRP</strong> within the good range; but I think .5 is even more desirable than .82 (says <em>Philip Miller</em>).</p>
<p>My <strong>fibrinogen</strong> level is lower than the reference range. The lab&#8217;s doctor says this is a good thing. I wonder why it is so low. High fibrinogen thickens the blood; low fibrinogen should thin the blood. This might be expected to make me bleed more easily, which I do not experience  &#8211; at least not yet   <img onclick="grin(':neutral:');" src="../wp-includes/images/smilies/icon_neutral.gif" alt=":neutral:" /></p>
<p><strong>Systemic inflammation</strong> is one of the 4 key &#8216;-ations&#8217; identified by <em>Philip Miller (Life Extension Revolution, Ch 7)</em> as being crucial to address if you wish to achieve healthy aging.</p>
<p>Treatment is simple; change your diet to exclude inflammatory factors (such as Omega 6 fatty acids) and take a mixture of herbs including:</p>
<ul>
<li>Nettles</li>
<li>Circumin (Turmeric)</li>
<li>Ginger</li>
</ul>
<p>and supplements, including:</p>
<ul>
<li>DHEA</li>
<li>Vitamin K</li>
<li>Bromelain</li>
</ul>
<p>Then you need to retest the blood to see if what you did worked. A lot of hassle, but it&#8217;s worth it to help avoid degenerative diseases.</p>
<p>Afterwards, an annual blood test will check everything is still ok. This should be part of a regular health routine.</p>
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